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Doctors Alexander believe that agranulocytosis in children is manifested due to the immaturity of the blood system, which matures by about 5 years. The development of complications with this form of neutropenia is not observed and, usually, this condition goes away on its own. The only thing that needs to be added is that antibiotics are used early for children with agranulocytosis as a prophylaxis for colds, and it is imperative that the mother and child register with a pediatrician, hematologist, allergist-immunologist.
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It reduces the production of granulocytes in the bone marrow and inhibits the production of antibodies. Prednisolone is used at a dose of 40 to 100 mg per day, up to normal numbers of granulocytes in the blood. Then the dose is slowly reduced.
Be sure to use leukopoiesis stimulants in the treatment of agranulocytosis. These include Sodium nucleinate, Leucogen, Pentoxil. Treatment continues for 3-4 weeks. It all depends on the patient's condition. Molgramostin, Leukomax are also used. With severe intoxication, detoxification therapy is used (increased tFever, pallor, vomiting, nausea, stool disorders, severe weakness, low blood pressure). Apply hemodez, glucose, isotonic sodium chloride solution or Ringer's solution. You can use platelet transfusion with severe hemorrhagic syndrome, which is caused by acute thrombocytopenia. Platelets obtained from one donor are transfused.
You can also use hemostatic drugs that stop bleeding. These include Ditsynon, Aminocaproic acid, etc. If severe anemia has developed, then transfusion of erythrocytes is used. Washed erythrocytes are often used to prevent complications after transfusion.
Prevention of agranulocytosis is a very important aspect of this syndrome, and therefore, the immune system should always be supported with vitamins. In summer, these are fruits, vegetables, and in winter, these are tableted vitamins that can strengthen the human immune system.
The information provided in this article is intended for informational purposes only and cannot replace professional advice and qualified medical assistance. At the slightest suspicion of the presence of this disease, be sure to consult your doctor! For the first time agranulocytosis was described in 1922 by W. Schultz. Simultaneously Friedemann described agranulocytic sore throat. With the widespread use of cytotoxic therapy (drug and radiation), as well as a large arsenal of new agents, the frequency of agranulocytosis has increased significantly. According to the mechanism of occurrence, agranulocytosis can be myelotoxic and immune.
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